Objective:To investigate the effect of Qianliean on the treatment of benign prostatic hyperplasia and the related mechanism.Method:Rat model of benign prostatic hyperplasia was established by castration followed by injection of testosterone.The rats were randomly divided into 5 groups:the normal group

the model group

the Qianliean high-dose group

the Qianliean low-dose group

Longbishu group.The rats were treated accordingly and sacrificed after 30 d.The prostates were sampled and weighed

and the prostate index was calculated.Light microscopic and immunohistochemical specimens were prepared and investigated.Result:Prostatic weight

prostatic index and basic fibroblast growth factorlevelsin（bFGF） expression levels in three treatment groups were significantly lower than that of the model group

in particular for the Qianliean of high-dose group.Model group showed marked pathological changes in prostate tissue

Qianliean low-dose group showed alleviated pathological changes in prostate tissue compared with the model group

high-dose group and Longbishu group rats prostate tissue showed obvious improvement in pathological changes.Conclusion: Qianliean can decrease prostate wet weight in rat and alleviate pathological damage in prostate.The mechanism may be related to the inhibition of prostate tissue bFGF release.