华蟾素注射液基于阿片受体的镇痛机制研究

巩仔鹏; 陈涛

doi:10.13422/j.cnki.syfjx.2010.15.046

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华蟾素注射液基于阿片受体的镇痛机制研究

药理 | 更新时间：2024-09-23

- 华蟾素注射液基于阿片受体的镇痛机制研究
- Studies on Analgesic Mechanism Based on Opioid Receptor for Cinobufagin Injection
- 中国实验方剂学杂志 2010年16卷第15期页码：120-122
- 作者机构：
  
  三峡大学医学院
- 作者简介：
- 基金信息：
  
  三峡大学硕士学位论文培优基金（2010PY067）
- DOI：10.13422/j.cnki.syfjx.2010.15.046
  中图分类号： R285
- 纸质出版日期：2010
- 稿件说明：
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[1]巩仔鹏,陈涛.华蟾素注射液基于阿片受体的镇痛机制研究[J].中国实验方剂学杂志,2010,16(15):120-122.

GONG Zi-peng, CHEN Tao. Studies on Analgesic Mechanism Based on Opioid Receptor for Cinobufagin Injection[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(15): 120-122.
[1]巩仔鹏,陈涛.华蟾素注射液基于阿片受体的镇痛机制研究[J].中国实验方剂学杂志,2010,16(15):120-122. DOI： 10.13422/j.cnki.syfjx.2010.15.046.

GONG Zi-peng, CHEN Tao. Studies on Analgesic Mechanism Based on Opioid Receptor for Cinobufagin Injection[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(15): 120-122. DOI： 10.13422/j.cnki.syfjx.2010.15.046.

摘要

目的:探讨华蟾素注射液基于阿片受体的镇痛机制。方法:用辐射热和机械刺激使雌性昆明小鼠后足产生缩足反应

测定其缩足潜伏期（paw withdrawal latency

PWL）作为热辐射痛和机械性痛痛阈指标

观察外周阿片受体阻断剂Naloxonemethiodide（纳洛酮的四价盐的衍生物

NAL-M）对华蟾素注射液升高小鼠PWL作用的影响。结果:外周阿片受体阻断剂NAL-M能够完全阻断华蟾素注射液升高小鼠PWL的作用

取消其镇痛作用。结论:华蟾素注射液的镇痛作用可能主要是通过外周的阿片受体介导的。

Abstract

Objective:To investigate the analgesic mechanism of cinobufagin injection based on opioid receptor.Method: Hind paw withdrawal latency of female Kunming mice was induced by radiant heat and mechanical stimuli.Moreover

the paw withdrawal latency（PWL） was measured to serve as indicator of pain threshold.Then

influence of naloxone methiodide

the peripheral opioid receptor antagonist

on PWL increase induced by cinobufagin injection in mice was investigated.Result:The analgesic effect and PWL increase induced by of cinobufagin injection could be completely blocked by naloxone methiodide.Conclusion: The peripheral opioid receptor may play a main role in the analgesic effect of cinobufagin injection.

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