Objective:To explore the mechanism of Bushen Wenyang Huayu（BSWYHY） on endometriosis（EMs）.Method: The peritoneal type endometriosis in SPF-grade female rats was established.They were then divided into 4 groups: BSWY high dose group（16）

BSWYHY low dose group（16）

danazol group（16）

model group（17）

and control group（12）.Immunohistochemistry was performed to examine the expression of HIF-1α and GLUT-1 in the ectopic endometrial tissues of the EMs model rats before and after treatment

and the volume change in endometriotic lesions before and after treatment was compared.Result:After treatment with high dose and low dose of BSWY and danazol

volumes of ectopic lesions were reduced obviously（P < 0.05）

and the volume of the high dose group demonstrated the most notable reduction（P < 0.01）.The expression of HIF-1α and GLUT-1 in ectopic EMs of the model group is significantly higher than that in eutopic endometrium in the control group（P < 0.01）.The BSWYHY high and low dose group and the danazol group were able to inhibit the high expression of HIF-1α and GLUT-1 substantially（P < 0.01）

with the high dose group as the best

followed by the low dose anddanazol group（P < 0.05）.Conclusion: BSWY can be an effective measure for reducing the high expression of HIF-1α and GLUT-1 for the treatment of EMs.