加味真武汤对肾间质纤维化大鼠TGF-β及FN表达的影响

张义兵; 熊玉兰; 杜贵友; 刘莎

doi:10.13422/j.cnki.syfjx.2010.15.061

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加味真武汤对肾间质纤维化大鼠TGF-β及FN表达的影响

药理 | 更新时间：2024-09-23

- 加味真武汤对肾间质纤维化大鼠TGF-β及FN表达的影响
- Effects of Jiawei Zhenwu Tang on Expression of TGF-β and FN in Rats with Renal Fibrosis
- 中国实验方剂学杂志 2010年16卷第15期页码：168-171
- 作者机构：
  
  1. 重庆医科大学中医药学院
  2. 中国中医科学院中药研究所
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2010.15.061
  中图分类号： R285.5
- 纸质出版日期：2010
- 稿件说明：
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[1]张义兵,熊玉兰,杜贵友,刘莎.加味真武汤对肾间质纤维化大鼠TGF-β及FN表达的影响[J].中国实验方剂学杂志,2010,16(15):168-171.

ZHANG Yi-bing1, XIONG Yu-lan2, DU Gui-you2, et al. Effects of Jiawei Zhenwu Tang on Expression of TGF-β and FN in Rats with Renal Fibrosis[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(15): 168-171.
[1]张义兵,熊玉兰,杜贵友,刘莎.加味真武汤对肾间质纤维化大鼠TGF-β及FN表达的影响[J].中国实验方剂学杂志,2010,16(15):168-171. DOI： 10.13422/j.cnki.syfjx.2010.15.061.

ZHANG Yi-bing1, XIONG Yu-lan2, DU Gui-you2, et al. Effects of Jiawei Zhenwu Tang on Expression of TGF-β and FN in Rats with Renal Fibrosis[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(15): 168-171. DOI： 10.13422/j.cnki.syfjx.2010.15.061.

摘要

目的:探讨加味真武汤对肾间质纤维化大鼠转化生长因子（TGF-β）及纤维连接蛋白（FN）表达的影响。方法:大鼠随机分为假手术组、模型组及治疗组

采用单侧输尿管梗阻（UUO）模型

术后7

21 d分别处死大鼠

测定肾脏指数、血肌酐（Cr）、尿素氮（BUN）;肾组织HE及Masson染色

观察肾脏病变;免疫组化法比较各组TGF-β及FN的表达。结果:术后随时间的延长

模型组和治疗组大鼠可见明显的肾间质纤维化改变

肾间质TGF-β

FN的表达明显高于假手术组（P<0.05）。治疗组大鼠肾间质纤维化程度及TGF-β

FN的表达均低于模型组（P<0.05）。结论:加味真武汤可降低UUO模型大鼠血Cr

BUN水平

抑制TGF-β表达

减少FN形成

对肾间质纤维化有积极的治疗意义。

Abstract

Objective: To investigate the mechanism of Jiawei Zhenwu Tang on renal interstitial fibrosis in model of SD rats.Method: Rat renal interstitial fibrosis model was produced by unilateral ureteral obstruction（UUO）

60 rats were randomly divided into three groups: sham group

UUO group

treaement group.Some rats of each group were killed respectively at 7

21 days after operation.Renal index

Cr and BUN were measured.The level of renal damage by HE and Masson staining was carried out.The expression of TGF-β and FN was analyzed by immunohistochemical method.Result: The level of renal index

BUN and renal damage in UUO group were highter than those in treament group.The expression of TGF-β was significantly higter than treatment group

and FN increased also.Conclusion: Jiawei Zhenwu Tang can downregulate the level of renal index

BUN in UUO group

inhibit the expression of TGF-β and accumulation of FN.Jiawei Zhenwu Tang has active effects in anti-fibrosis.

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