袪脂保肝颗粒对高脂饮食所致脂肪肝大鼠的药效观察及机制初探

于永军; 刘清新; 张秋雨; 祁秀玲; 王国明; 王俊峰

doi:10.13422/j.cnki.syfjx.2010.18.033

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袪脂保肝颗粒对高脂饮食所致脂肪肝大鼠的药效观察及机制初探

药理 | 更新时间：2024-09-23

- 袪脂保肝颗粒对高脂饮食所致脂肪肝大鼠的药效观察及机制初探
- Experimental Study of Quzhi Baogan Granules on Rat’s Fatty Liver Induced by High Fat Diet
- 中国实验方剂学杂志 2010年16卷第18期页码：166-168
- 作者机构：
  
  1. 沧州医学高等专科学校
  2. 河北天成药业有限公司
- 作者简介：
- 基金信息：
  
  河北省科学技术与发展指导性计划课题（07276465）
- DOI：10.13422/j.cnki.syfjx.2010.18.033
  中图分类号： R285.5
- 纸质出版日期：2010
- 稿件说明：
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[1]于永军,刘清新,张秋雨,祁秀玲,王国明,王俊峰.袪脂保肝颗粒对高脂饮食所致脂肪肝大鼠的药效观察及机制初探[J].中国实验方剂学杂志,2010,16(18):166-168.

YU Yong-jun1, LIU Qing-xin1, ZHANG Qiu-yu1, et al. Experimental Study of Quzhi Baogan Granules on Rat’s Fatty Liver Induced by High Fat Diet[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(18): 166-168.
[1]于永军,刘清新,张秋雨,祁秀玲,王国明,王俊峰.袪脂保肝颗粒对高脂饮食所致脂肪肝大鼠的药效观察及机制初探[J].中国实验方剂学杂志,2010,16(18):166-168. DOI： 10.13422/j.cnki.syfjx.2010.18.033.

YU Yong-jun1, LIU Qing-xin1, ZHANG Qiu-yu1, et al. Experimental Study of Quzhi Baogan Granules on Rat’s Fatty Liver Induced by High Fat Diet[J]. Chinese journal of experimental traditional medical formulae, 2010, 16(18): 166-168. DOI： 10.13422/j.cnki.syfjx.2010.18.033.

摘要

目的:研究袪脂保肝颗粒对高脂饮食所致脂肪肝大鼠的防治效果及机制。方法:采用高脂饲料连续12周复制大鼠脂肪肝模型

期间分别对不同组别大鼠进行相应药物干预

观察袪脂保肝颗粒（24

6 g.kg-1）连续ig 12周对脂肪肝的防治作用

并初步探讨其疗效机制。结果:与空白对照组相比

模型组肝组织胆固醇（CHO）

甘油三酯（TG）水平有显著升高（P<0.01）

血清天门冬氨酸氨基转移酶（AST）、丙氨酸氨基转移酶（ALT）显著升高

肝脏病理呈脂肪性肝病变

并伴有明显细胞损伤和组织坏死;与模型组比较

祛脂保肝颗粒各剂量组肝TG

CHO均显著降低（P<0.05或P<0.01）;血清AST

ALT显著降低

肝脏病理损伤减轻。结论:袪脂保肝颗粒对脂肪肝具有较好的防治作用

可通过抗氧化机制减轻肝细胞损伤。

Abstract

Objective:To observe the effects of Quzhi Baogan Granules on the rat’s fatty liver.Method:The rat’s fatty liver was induced by high fat diet.The different groups were given different drugs

to observe the efficacy of Quzhi Baogan Granules on the rat’s fatty liver

meanwhile to investigate the mechanism of the granules on the rat’ s fatty liver.Result:Compared with blank control group

liver tissue CHO

TG levels in the models were increased significantly（P < 0.01）

serum AST

ALT were significantly increased（P < 0.01）.Pathological investigation showed that liver cell steatosis was took place associated with cell injury and necrosis.Compared with model group

the liver tissue CHO

TG levels in the Quzhi Baogan high-dose group

mid-dose group

low-dose group were decreased obviously（P < 0.01 or P < 0.05）

the serum AST

ALT were decreased obviously（P < 0.01 or P < 0.05）

meanwhile the liver injury were alleviated.Conclusion:Quzhi Baogan Granules can reduce liver cell injury through the antioxidant mechanism

it can prevent and treat the rat’s fatty liver induced by high fat diet.

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