Objective:To observe IL-8 and TNF-α mRNA expression of rabbit sinus mucosa of Biyuanshu treatment of chronic rhinosinusitis（CRS） model

and explore the possible mechanism of Biyuanshu treatment of CRS.Method: Sixty new Zealand rabbits fed one week after adaptation and were randomLy divided into normal group

model group

sham operation group

Biyuanshu group

western medicine group

12 in each group.Firstly CRS model have established

then Biyuanshu group and western medicine group were given 1.5 mL.kg-1 of BiYuanShu or 25 mg.kg-1of clarithromycin every day in14 days

finally they were sacrificed to take sinus mucosa

HE staining were observed by light microscopy and IL-8 and TNF-α mRNA expression of sinus mucosa were detected by real-time quantitative PCR.Result: In model group

the sinus mucosa showed chronic inflammation and mucosal infiltration of inflammatory cells

and epithelial cells and glands and hyperplasia of goblet cells were found

IL-8 and TNF-α mRNA expression of sinus mucosal were higher than normal group significantly（P < 0.01）.In Biyuanshu group

sinus mucosa have good repair

and inflammatory cells and glands and goblet cell hyperplasia were not obvious

IL-8 and TNF-α mRNA expression of sinus mucosal were lower than model groupsignificantly（P < 0.01）

Biyuanshu group and normal group have no significant difference.Conclusion: The mechanism of Biyuanshu treatment of CRS may be related to regulation of IL-8 and TNF-α mRNA expression of sinus mucosal.