Objective:To determine the optimal processing method for Fructus Forsythiae.Method: HPLC was applied on the determination with Alltima C18 column（4.6 mm × 250 mm

5 μm） and methanol-water as mo-bile phase by a gradient elution program at a flow rate of 0.8 mL.min-1.The detection wavelength was at 280 nm and column temperature was at room temperature.Result: The regression equation of Forsythiaside wasY = 959 631.703 1X + 250 467.648 4

r = 0.999 4

Linear range was 1.5-15 μg

The regression equation of phillyrin was Y = 883 203.205 8X-9 047.738 3

r = 0.999 4

Linear range was 0.145-1.45 μg.The average recovery of Forsythiaside and Phillyrin was 97.9% with RSD 2.30% and 99.2% with RSD 2.27%（n = 6） respectively.Content of the Forsythiaside and Phillyrin was in the maximum yield with the processing methods of steaming for 20-30 min steaming.Conclusion:The method was accurate and repeatable

can be applied to the quality control of Fructus Forsythiae.The optimal processing method of Fructus Forsythiae was steaming for 20-30 min.