SONG Jin-chun1, HUANG Wei2. Preparation and Releasing Properties of Curcumin and Pluronic P123 Copolymer Micelle[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(1): 1-4.
SONG Jin-chun1, HUANG Wei2. Preparation and Releasing Properties of Curcumin and Pluronic P123 Copolymer Micelle[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(1): 1-4. DOI: 10.13422/j.cnki.syfjx.2011.01.013.
Objective:Curcumin and pluronic P123 copolymer micelle was prepared to investigate the releasing properties of curcumin in vitro.Method: The nanomicelle was prepared by thin film aqueous method
and curcumin was determined by HPLC
releasing properties in vitro were investigated by dynamic dialysis.Result:The average diameter of curcumin pluronic P123 copolymer micelle was 64.97 nm with entrapment rate of 71.74% and drug-loading rate of 1.62%;the releasing properties in vitro were accorded with weibull equation.Conclusion:The effect of delayed release of curcumin in vitro by curcumin pluronic P123 copolymer micelle was good.