LIU Jun1, ZHANG Jian-jun2. Optimization of Processing Parameters for Extraction of Total Glucoside of Paeony in Paeony Dispensing Granule Using Box-Behnken Experimental Design[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(1): 9-13.
LIU Jun1, ZHANG Jian-jun2. Optimization of Processing Parameters for Extraction of Total Glucoside of Paeony in Paeony Dispensing Granule Using Box-Behnken Experimental Design[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(1): 9-13. DOI: 10.13422/j.cnki.syfjx.2011.01.015.
Objective:Optimization of the processing parameters was applied for the extraction of total glucoside of paeony in paeony dispensing granule.Method: Based on the results of single-factor-at-a-time-technique
Box-Behnken experimental design combining with response surface methodology(RSM) was employed
with the soaking time(X1)
the water addition(X2)
the extraction time(X3) as the independent variables.The response variable was the amount of total glucoside of paeony.Result:The optimization processing parameters was as follows: X1
X2 and X3 levels of 98.4 min
12 times and 69.8 min respectively.Conclusion:The observed responses were in close agreement with the predicted values of the mathematic models
and the Box-Behnken experimental design is suitable for optimizing the extraction of total glucoside of paeony in paeony dispensing granule.