新疆紫草提取物凝胶剂的制备及质量考察

李娜; 买尔丹·马合木提

doi:10.13422/j.cnki.syfjx.2011.01.016

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新疆紫草提取物凝胶剂的制备及质量考察

工艺与制剂 | 更新时间：2024-09-23

- 新疆紫草提取物凝胶剂的制备及质量考察
- Study on Preparation and Quality Examination of Arnebia euchroma Extracts Gel
- 中国实验方剂学杂志 2011年17卷第1期页码：14-17
- 作者机构：
  
  1. 新疆医科大学附属肿瘤医院
  2. 新疆医科大学药剂教研室
- 作者简介：
- 基金信息：
- DOI：10.13422/j.cnki.syfjx.2011.01.016
  中图分类号： R283.6
- 纸质出版日期：2011
- 稿件说明：
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[1]李娜,买尔丹·马合木提.新疆紫草提取物凝胶剂的制备及质量考察[J].中国实验方剂学杂志,2011,17(01):14-17.

LI Na1, Maierdan·Mahemuti1. Study on Preparation and Quality Examination of Arnebia euchroma Extracts Gel[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(1): 14-17.
[1]李娜,买尔丹·马合木提.新疆紫草提取物凝胶剂的制备及质量考察[J].中国实验方剂学杂志,2011,17(01):14-17. DOI： 10.13422/j.cnki.syfjx.2011.01.016.

LI Na1, Maierdan·Mahemuti1. Study on Preparation and Quality Examination of Arnebia euchroma Extracts Gel[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(1): 14-17. DOI： 10.13422/j.cnki.syfjx.2011.01.016.

摘要

目的:制备新疆紫草提取物凝胶剂并考察其初步的质量。方法:采用正交试验设计

以卡波姆-940、丙二醇的用量及pH为考察因素

以凝胶剂的光泽度、涂展性、均匀度、离心性为指标进行综合评分

筛选优化处方

制备新疆紫草凝胶剂。采用紫外分光光度法测定左旋紫草素的含量。结果:优化处方为卡波姆-940 0.7%

丙二醇10%

pH 6.5

左旋紫草素在5～30mg.L-1与吸收度呈良好的线性关系

相关系数为0.999 9。平均加样回收率为95.7%（RSD 3.06%

n=6）。体外释药曲线符合Higuchi方程。结论:该凝胶剂制备工艺简单

质量可控

各项指标符合凝胶剂的质量标准。

Abstract

Objective:To prepare the Arnebia euchroma extracts gel（AJEG）and examine the initial quality.Method:The AJEG were prepared through the orthogonal design to optimize the prescription

in which the glossiness

spreading ability

uniformity and the centrifugal resisting were evaluated comprehensively as indexes

with the amount of carbopol-940

propylene glycol and pH value as observing factors.The content of L-shikonin was determined by UV spectrophotometer.Result:The prescription optimized was composed of 0.7% carbopol-940

10% propylene glycol and pH was 6.5·L-shikonin was linear in the range of 5-30 mg·L-1 with the correlation coefficient of 0.999 9 and average recovery was 95.7% with RSD 3.06%（n = 6）.The releasing in viro was characterized by the higuchi equation.Conclusion:The preparing technology was simple

and the quality of AJEG is controllable.The indexes were accord with the standard of gel.

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