Objective: To compare antipyretic

diuretic

anti-tumor and analgesic effects of extracts from cultural and wild Radix Sophorae Flavescentis.Method: The antipyretic action was monitored by dried yeastinduced fever in rats.The diuretic effect was observed in mouse model by collecting and testing urine volumes in different intervals.The analgesic effects were discussed by adopting acetic acid writhing and hot plate test in mice.Result: Both the extracts from cultural and wild Radix Sophorae Flavescentis 1

2

4 g·kg-1 significantly reduced the fever induced by dried yeast and increased urine volumes in rats at all the intervals.Both of them 3

6 g.kg-1 remarkably enhanced the threshold of pain by hot plate

reduced the numbers of writhing and prolonged the latencies of paw licking in mice

showing significant analgesic effects.Conclusion: There is no significant difference in antipyretic

diuretic and analgesic effects between extracts from cultural and wild Sophorae flavescentis.The results provide experimental evidence for cultural Sophorae flavescentis replacing wild ones in clinic.