四逆散对实验性溃疡性结肠炎大鼠IL-1β的影响

卢健; 马骥; 王丽娜; 林蔗茹; 于彩娜

doi:10.13422/j.cnki.syfjx.2011.01.042

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四逆散对实验性溃疡性结肠炎大鼠IL-1β的影响

药理 | 更新时间：2024-09-23

- 四逆散对实验性溃疡性结肠炎大鼠IL-1β的影响
- Study on Influence of Sini Powders on IL-1β in Rats with Experimental Ulcerative Colitis
- 中国实验方剂学杂志 2011年17卷第1期页码：103-105
- 作者机构：
  
  1. 辽宁中医药大学方剂学科
  2. 辽宁卫生职业技术学院
- 作者简介：
- 基金信息：
  
  辽宁省教育厅项目（2006T093）
- DOI：10.13422/j.cnki.syfjx.2011.01.042
  中图分类号： R285.5
- 纸质出版日期：2011
- 稿件说明：
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[1]卢健,马骥,王丽娜,林蔗茹,于彩娜.四逆散对实验性溃疡性结肠炎大鼠IL-1β的影响[J].中国实验方剂学杂志,2011,17(01):103-105.

LU Jian1, MA Ji1, WANG Li-na1, et al. Study on Influence of Sini Powders on IL-1β in Rats with Experimental Ulcerative Colitis[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(1): 103-105.
[1]卢健,马骥,王丽娜,林蔗茹,于彩娜.四逆散对实验性溃疡性结肠炎大鼠IL-1β的影响[J].中国实验方剂学杂志,2011,17(01):103-105. DOI： 10.13422/j.cnki.syfjx.2011.01.042.

LU Jian1, MA Ji1, WANG Li-na1, et al. Study on Influence of Sini Powders on IL-1β in Rats with Experimental Ulcerative Colitis[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(1): 103-105. DOI： 10.13422/j.cnki.syfjx.2011.01.042.

摘要

目的:探讨四逆散对实验性溃疡性结肠炎（UC）大鼠白介素-1β（IL-1β）的影响

以及君臣配伍在组方中的作用。方法:将实验动物分为5组

采用免疫法造模

以大鼠结肠组织大体情况、结肠组织病理变化和IL-1β水平作为观测指标

用ELISA法检测大鼠结肠黏膜组织和血清IL-1β水平。结果:模型组大鼠结肠组织黏膜层可见溃疡形成

且有明显的炎症存在

认为本实验造模成功;模型组大鼠血清和结肠黏膜组织的IL-1β分别为（841.93±95.64）ng·L-1和（75.06±2.15）ng·L-1均显著高于正常组（P<0.01）

灌服柴芍枳（1.31 g·kg-1）和柴芍（0.88 g·kg-1）后大鼠血清和结肠黏膜组织IL-1β显著降低（P<0.05）

而灌服四逆散（1.75 g·kg-1）后大鼠结肠黏膜组织IL-1β（72.62±2.67）ng·L-1明显减少（P<0.01）

但血清IL-1β（1015.52±176.47）ng·L-1却显著升高。结论:四逆散能够通过调节IL-1β来干预实验性UC

其全方发挥作用环节可能为抑制IL-1β由外周血单核细胞向炎症肠黏膜的移行;而方中君、臣药物配伍的作用环节为抑制IL-1β的分泌。

Abstract

Objective: To observe the influence of Sini Powders on interleukin-1 beta（IL-1β） of rats with experimental ulcerative colitis（UC） and effects of so-called the monarch drug and ministerial drug in the prescription.Method: The experimental animals were divided into 5 groups

and modeling was made by immunization.IL-1β levels in rats’ colon mucosal tissues and serum were detected by ELISA.Result: Colon pathological changes with obvious inflammation were found after modeling.The levels of IL-1β in rats of the model group were higher than those in the normal group（P < 0.01）.After feeding Chaishaozhi and Chaishao

IL-1β levels of UC rats were obviously reduced（P < 0.05）.After feeding Sini Powders

IL-1β levels in UC rats’colon mucosal tissue were markedly reduced（72.62 ± 2.67）ng.L-1

（P < 0.01）

but they were obviously increased in serum（1015.52 ± 176.47）ng.L-1.Conclusion: We speculate that Sini Powders can interfere with experimental UC by adjusting IL-1β levels.Sini Powders may play a role in inhibiting moving of IL-1β from the mononuclear cells in peripheral blood to intestinal mucosa

and the compatibility of the monarch drug and ministerial drug play a role in suppressing secretion of IL-1β.

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