Objective: To observe the effects of Astragali Complanati Semen（ACS） on model animals with spermatogenic disturbance and deficiency of kidney yang.Method: The models of spermatogenic disturbance were established by feeding gossypol acetic acid（GAA） in rats and intraperitoneal injection of cyclophosphamide in mice

sperm quantities of animals in various groups were counted

sperm activities were observed

and the levels of follicle-stimulating hormone（FSH）

luteinizing hormone（LH） and testosterone（T） were determined by radio immunoassay.The models of deficiency of kidney yang were established by feeding cortisone acetate.Rectal temperature

swimming time

spontaneous activity

testis weight

and seminal vesicle weight were measured.Result: SAC extract 0.2

0.4 g.kg-1 markedly improved sperm quantity

sperm activity and the level of T in serum

decreased aberration rate of sperm and the level of LH and FSH in serum.It could markedly improve rectal temperature

swimming time

locomotor activity

testis index

and semina1 vesicle index.Conclusion: ACS extract can markedly promote the generation of sperm in spermatogenie disturbance animals

ameliorate serum sex hormone levels

increase the level of quality of sperm

and has remarkable therapeutic effect on deficiency of kidney yang in mice.