Objective: To investigate the potency and safety of Jiangya Granules（Jyg） on hypertension.Method: Renal hypertension model was established by ligation of the left renal artery.Healthy rats were divided into a model group

a normal control group

a positive control group

a high dose of Jyg group

a middle dose of Jyg group and a low dose of Jyg group（11.4

5.7

2.9 g.kg-1）to observe the effect of Jyg on lowering blood pressure.In addition

the action of vasodilation was observed by microscope to record vessel diameters of arteriolae and veinules in mice’s ears.The experiments in acute toxicity were carried out by oral administration of Jyg to mice given twice a day with tolerable concentration and volume to observe their responses immediately after the administration and continuously for 14 days.Result: All the 3 different dosages of Jyg could significantly depress blood pressure of experimental renal hypertension in rats

and expand the arteriolae and veinules in mice’s ears.After 14 days’continuous observation

no mouse was found dead.Their weight increased

and no significant toxicity occurred by naked eyes.Conclusion: Jiangya Granule can obviously lower blood pressure

and it is preliminary proven to be safe.