Objective: To explore the influence of Jianfei capsule to leptin receptor（LR） behind signal transcription system and the mechanism at Molecular level.Method: The Seventy-seven male conventional Sprague-dawleg（SD） rats were divided into control diet group（n = ten） and high fat group（n = sixty-seven） randomly

there is no significant difference on the side of weight（P < 0.05）.And control diet group were fed with normal diet and high fat diet respectively.After eight weeks

thirty-five rats from high fat diet group were successfully made into obese models.Their body weight were all higher 20% than the average weight in control diet group.They were randomly divided into three groups.Obese model group

high dosage group and low dosage group.All of the groups were replaced by normal diet.Respectively by 13.7

6.85 g·kg-1

high and low dosage group were given Jianfei capsule decoction（10 mL·kg-1·d-1）

simultaneously

control group and obese model group were givenequivoluminal distilled water.After oral administration for four weeks

all of the rats were anaesthetized

weighted.After adopt blood from aorta abdominalisthe

Hypothalamic and genital fat

liver and heart were collected quickly.Gene expression of JAK1

STAT3

STAT6 of Hypothalamic and adipose tissue were detected by non-radioactive in situ-hybridization.Result:There are the high gene expression of JAK1

STAT3

STAT6 not only in Jianfei capsule but also in obese model group;there is some difference and dose-effect relationship between high dosage group with low dosage group.Third

different concentration Jianfei capsule can improve gene expression of JAK1

STAT3

STAT6 of hypothalamus.Conclusion:The mechanism that Jianfei capsule take effect through its influence to LR behind signal transcription system is still needed to be investigated further.