Objective: To explore the effects of nourishing kidney herbs on dopamine of striatal neurons in mouse model of parkinson ’s disease.Method: Fourty five Parkinson’s disease model mice were randomly divided into five groups:Epimedii Folium group

Ligustri Lucidi Fructus group

Polygonatum group

selegiline group and model control group.Nine normal male C57BL /6J strains of mice were used as the normal control group.The normal control group and model control group were adminstraed with water

the mice in Epimedii Folium group

Ligustri Lucidi Fructus group

Polygonati Rhizoma group and selegiline group were adminstraed with Epimedii Folium

Ligustri Lucidum Fructus

Polygonatum and selegiline water decoction（each 0.5 mL

bid）.After for 4 weeks

striatal neurons were quickly separated in the ice.Immunohistochemistry was used to detect the level of TH

HPLC-Electrochemical was used to detect the level of DA and metabolites.Result: The levels of TH

DA

DOPAC in Epimedii Folium group were significantly higher than that in model control group and selegiline group（P < 0.05）

were not significantly lower than that in the blank control group;The levels of DA were significantly higherin Ligustri lucidi Fructus group and Polygonati Rhizoma group than that in the model group（P < 0.05）

while the levels in Ligustrum lucidum group was higher than selegiline group（P < 0.05）

but not higher than that in the blank control group.Conclusion: The nourishing kidney herbs Epimedium Folium

Ligustri Lucidi Fructus and Polygonati Rhizoma can improve DA of striatal neurons in mouse model of parkinson ’s disease

but the mechanism is not exactly the same.Further study is needed.