Objective: To explore the effect of Sanhuang Xiexintang on the expressions of nuclear-κB（NF-κB） and interleukin-6（IL-6） in gastric mucosa of rats after severe traumatic brain injury.Method: Female 35 and male 35（total 70） Wistar rats were collected.All rats were randomly divided into normal control group（10 rats）

model group（30 rats）

and Chinese traditional medicine group（30 rats）.The two later groups at hour 6.24.72 post-trauma（each group 10 rats）.Except the control group

the other rats were subjected to severe traumatic brain injury with a free-falling object which following Feeney’s method.A series of stomach samples were obtained directly 6.24 and 72 hours respectively after operation in every groups with optical microscope histopathology tests of stomach were performed.Immunochemistry（IHC） was used to detect the expression of IL-6

NF-κB on stomach at different time point.Result: In normal control group rats

the ecderon of gastric mucosa structurual integrity andglandular organ line up in order;In model groups the gastric mucosa appeared defect as well as inflammatory cell infiltrated

formed superficial erosion and vasodilatation nearby.In the Chinese traditional medicine groups especially in the 72 h group the mucosal damage could be lessened and the edema in capillary vessel and interstitial tissue could be alleviated;NF-κB and IL-6 were stained in endochylema.Every groups expressed.Compared with control group

the expression of IL-6 and NF-κB in model 24 h and 72 h groups were significantly increased（P < 0.01 ～ 0.05）.Compared with model 24 h group

the expression of IL-6 in Chinese traditional medicine 24 h group were obviously decreased（P < 0.05）;Compared with model 72 h group and the same 24 h group

the expression of IL-6 and NF-κB in Chinese traditional medicine 72 h group were obviously decreased too（P < 0.01 ～ 0.05）.Conclusion: San huang Xiexintang inhibits the inflammatory reaction by inhibiting the expressions of nuclear-κB and interleukin-6

which may be one of the mechanisms of its stomach-protective effects.