LIU Yuan-jie1, LI Liang2, WANG Dong-hong3, et al. Effects of Huixiang Zhizhu Soup on SOD,MDA and Pathomorphology in Rats with Adhesive Intestinal Obstruction[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(1): 165-168.
LIU Yuan-jie1, LI Liang2, WANG Dong-hong3, et al. Effects of Huixiang Zhizhu Soup on SOD,MDA and Pathomorphology in Rats with Adhesive Intestinal Obstruction[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(1): 165-168. DOI: 10.13422/j.cnki.syfjx.2011.01.058.
Objective: To observe the effects of Huixiang Zhizhu soup(HX-S) on superoxide dismutase(SOD)
malondialde hyde(MDA) and pathomorphology in rats with adhesive intestinal obstruction
and provide experimental evidence for the realitionship of SOD
MDA and pathomorphology change with the adhesive intestinal obstruction of HX-S.Method:The Wister rat model of adhesive intestinal obstruction.One hundred and eight rats were randomly divided into the normal group
model group
Dachengqi soup(DS) group
HX-S low dosage(HX-SL)group
HX-S middle dosage(HX-SM)group and HX-S high dosage(HX-SH)group.Succeed in the model.The rats were killed after three days
five days and seven days adopt the intestine tissue to
with 6 rats in each subgroup.The levels of SOD and MDA in intestine tissue were determined by radioimmunoassay
adopt the intestine tissue to observe the change of pathomorphology.Result: Compared with those in normal group
the level of intestine tissue SOD were decreased obviously
and the level of intestine tissue MDA were increased obviously in model group(P < 0.05);Compared with those in model group
the level of intestine tissue SOD were increasedobviously
and the level of intestine tissue MDA were decreased obviously(P < 0.05) and pathomorphology investigation small intestine injury had been restored in model group in DS group
HX-SL group
HX-SM group and HX-SH group.Conclusion: HX-S has good action effect in rats with adhesive intestinal obstruction
and its mechanism may be correlated with anti-intestine tissue peroxidation.