Objective: To investigate protective effects of sapindoside on experimental myocardial ischemia in rats.Method: Using the method of ligation of left descending coronary artery to establish the rat model of myocardial ischemia.Besides a sham-operated group

successfully-made-model rats were divided into a model group

a positive control group

a low dose

a medium dose and a high dose of sapindoside groups with 10 rats in each group

in which the drug was given by stomach irrigating for consecutive 28 d.ECG of each rat was measured before surgery

immediately

and 1

3

7

10

14

21 and 28 d after surgery.The scope of myocardial infarction

the content of superoxide dismutase（SOD）

glutathione peroxidase（GSH-Px） and malonaldehyde（MDA） in each rat serum were measured after the drug was used for 28 d.Result: Within certain dose range of sapindoside

the ECG S-T segment elevation levels in model rats were obviously reduced

the myocardial infarct sizes were decreased

the activities of SOD and GSH-Px in rat serum were enhanced

and the contents of MDA were reduced.Conclusion: sapindoside can effectively protect myocardial ischemic injury of rats.Its role may be related to scavenging oxygen free radicals

enhancing the activity of antioxidant enzyme

and inhibiting lipid peroxidation.