CHENG Qi-lai, LI Hong-liang, ZHANG Dao-ying. Detection of Salbutamol in some Cough Preparations of Traditional Chinese Medicine by HPLC[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(2): 80-82.
CHENG Qi-lai, LI Hong-liang, ZHANG Dao-ying. Detection of Salbutamol in some Cough Preparations of Traditional Chinese Medicine by HPLC[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(2): 80-82. DOI: 10.13422/j.cnki.syfjx.2011.02.029.
HPLC检测止咳中药制剂中的沙丁胺醇
摘要
目的:建立检测止咳中药制剂中非法掺入的化学止咳平喘药物沙丁胺醇方法。方法:选用Agilent C18(4.6 mm×150 mm
Objective:To develop a quantification method for the detection of salbutamol
a cough medicine
adulterated illegally in some cough preparations of traditional Chinese medicine.Method:Salbutamol was detected by HPLC on an Agilent Eclipse XDB-C18 column(4.6 mm × 150 mm
5 μm) with methanol-potassium dihydrogen phosphate(adjust pH to 7.0 with phosphoric acid)(5∶95) as a mobile phase.According to the detected compound retention time
compared with the reference substance
the chemical drug salbutamol that was adulterated illegally into TCM preparations could be identified.Result:The conditions developed in this study could entirely separate from the cough medicine salbutamol added into TCM preparations.Using this method to detect 20 kinds of preparations and compared with the corresponding standard substances
salbutamol was not detected in 20 kinds of samples.Conclusion:The method is selective
sensitive and can be used as an effective means to detect illegal TCM preparation.