Objective:To observe the effects of Huanglian Jiedu Decoction on prothrombotic state（PTS） in spontaneous hypertension rats（SHR）.Method:Twenty-four SHR were randomly divided into the Huanglian Jiedu Decoction treated group

captopril treated group and model group;eight Wistar-Kyoto Rats were used as the blank group.The groups were treated by Huanglian Jiedu Decoction

captopril and distilled water respectively for six weeks.Blood pressure（BP） were measured at the beginning of the experiment and the end of every week in the experiment

and after six weeks

thromboxane A2（TXA2）

6-Keto-prostaglandin（6-K-PG）

nitric oxide（NO）

endothelin-1（ET-1）

tissue type plasminogen activator（t-PA）

Plasminogen activator inhibitor-1（PAI-1）

homocysteic acid（Hcy） and von Willebrand factor（vWF） of plasma were determined respectively.Result: Huanglian Jiedu Decoction could control the BP of the SHR and decrease the content of TXA2

ET-1

Hcy

vWF（P < 0.05 or P < 0.01） and increase the content of 6-K-PG

NO（P < 0.05 or P < 0.01）.Conclusion:Huanglian Jiedu Decoction could control the BP and improve the PTS in the SHR.