Objective:To study effects of Ligustri Lucidi Fructus on hepatocellular carcinoma cells（HCC） and its influence on vascular endothelial growth factor（VEGF）

transforming growth factor-alpha（TGF-α） and to discuss its mechanism of action.Method:We examined the inhibition of PLC /PRF /5 cells after incubation with the extract of L.lucidi Fructus by 3-[4

5-dimethylthiazol-2-yl]-2

5-diphenyltetrazolium bromide（MTT）.We examined the expressions of VEGF

TGF-α by enzyme-linked immunosorbent assay（ELISA）.PLC /PRF /5 tumor-bearing mice mode was established by the inoculation of cancer cell suspension subcutaneously in mice’s right anterior limbs.We examined inhibition rate of tumor in mice treated with L.lucidi Fructus for 14 d intragastrically.We further examined the expressions of angiogenic factors in HCC xenografts by immunohistochemical methods.Result:The extract of L.lucidi Fructus can inhibit the proliferation of tumor cell growth as well as the expressions of VEGF and TGF-α.Conclusion:The extract of L.lucidi Fructus has anti-tumor effect

and the release of VEGF and TGF-α might be one of it’s anti-tumor mechanism.