Objective:To study the effects of Huanglian Jiedu Decoction（HJD） on blood lipid and oxygen radical metabolism in experimental hyperlipidemia rats.Method: Fifty SD rats were randomly divided into normal control group

untreated group

lipitor group（0.2 mg·kg-1）

and low-and high-dose HJD group（6

12 g·kg-1）.Except the normal control group

rats in the other groups were fed with high fat diet for 15 days to induce hyperlipidemia.Then the rats were administered with corresponding drugs for 8 weeks.After treatment

the serum levels of total cholesterol（TC）

triacylglycerol（TAG）

low-density lipoprotein cholesterol（LDL-C） and high-density lipoprotein cholesterol（HDL-C） were assayed.The activities of superoxide dismutase（SOD） and glutathione peroxidase（GSH-Px） and the level of malondialdehyde（MDA） were measured.The histological changes in liver tissues were observed.Result: Compared with the untreated group

HJD could significantly decrease the serum levels of TC

TG

LDL-C and MDA

increase the serum level of HDL-C and the activities ofSOD and GSH-Px

and relieve the fatty degeneration of hepatic cells.Conclusion: HJD has the potential effect to regulate the lipid metabolism of hyperlipidemia rats

increase antioxidant activity and improve the histopathological injury of the liver.