Objective:To observe Qinxiang granules（Qinxiang Zhixie tablets） influence on small intestinal mucosa lymphocytes in suckling mice with HRV infection.Method:The suckling mice were randomly divided into 7 groups

the normal control group

the other six groups as the model of HRV infection.The normal control group was treated with NS

and the other experimented groups differently treated with Qinxiang granules（High dose/medium dose/low dose

1.44/0.72/0.36 g·kg-1）

ribavirin（0.11 g·kg-1）

Changkang tablets（0.52 g·kg-1） for 5 days.The changes in small intestinal was observed.Result:Compared with the normal control group

in each treatment group and model group reduction of small intestinal CD4+lymphocytes was statistically significant（P<0.05）.Compared with model group

in the treatment groups small intestinal CD4+lymphocytes were increased in high

medium dose groups and ribavirin group the increase was significant（P<0.05）;comparied with normal control group

in each treatment group and model group

the number of small intestinal CD8+lymphocytes was increased to various degree.Compared with model group

in the treatment groups small intestinal CD8+lymphocytes werereduced

and the differences were significant（P<0.05）.Conclusion: Qinxiang granules can increase small intestinal CD4+

lower CD8+in suckling mice.The Qinxiang granules is conducive for enhancing the protection of the intestinal mucosa with lymphocytes

and reducing mucosal lesions.