Objective:To investigate the antioxidant and α-glucosidase inhibitory activities of Polygonum perfoliatum L.Method: The total antioxidant capacity was determined by using the [2

2′-azino-bis-3-ethylbenzothizaoline-6-sulfonic acid]diammonium salt（ABTS） radical scavenging

1

1-diphenyl-2-picryl-2-picryl-hydrazyl（DPPH） radical scavenging and ferric reducing antioxidant power（FRAP） assay and α-glucosidase inhibitory activity was determined by external screening model.Result:The ethyl acetate and methanol extracts of P.perfoliatum L.had antioxidant activity

and the methanol extract had the best activity;the Trolox equivalents in ABTS

DPPH and FRAP methods were 701.60±25.35

338.66±11.26

392.52±12.89 μmolTE·g-1 respectively.Three extracts of P.perfoliatum L.had good α-glucosidase inhibitory activity

and the methanol extract was the best

which IC50 value was 16.14 mg.L-1.Conclusion:The methanol extract had the best antioxidant and α-glucosidase inhibitory activities

speculated it would be used for the treatment of diabetes.