Objective: To verify and further define the active components alignment of antipyretic and provide the scientific basis date for the clinical curative effect of quality standards on Huangjinju.Method:On the basis of determining the active components alignment by HPLC analysis about classic prescription

take the fever model rats were made by dry yeast and provide the model of the fever for 10 hours of temperature detection

and set up the Huangjinju decoction group and the active components alignment group（high

middle and low dose） and the Positive group to compare with the model group

while similar symptoms common drugs used to synchronize the control Shuanghuanglian oral.Result:Comparing with the model group

there was significant difference（P < 0.01） among the control group and the treatment group（P < 0.05）.the active components alignment（high

middle and low dose） groups when body temperature in rats 2-6 hours after treatment temperature were lower than the model group

with significant antipyretic effect.Conclusion: The active components alignment of Huangjinju（baicalin

Chlorogenic acid

orientin and vitexin） really have significant antipyretic effects

so they are the active components alignment of antipyretic on Huangjinju.