Objective:To investigate the effects of leaves of Exochorda serratifolia on the glucose tolerance in normal and diabetic mice and to study the hypoglycemic effect on STZ induced diabetic mice.Method:First

diabetic mice model was induced by STZ（150 mg·kg-1）.Normal or diabetic mice were given a single dose of the water extract from leaves and the 80% EtOH extract from leaves

and the changes of glucose tolerance were observed respectively;Second

The water extract and the 80% EtOH extract was administrated at different does（9.5

3.8 g·kg-1） to the STZ induced mice for 10 days.The mice of positive control group were given meformin hydrochloride（333 mg·kg-1）.And then

the levels of blood glucose were inspected.Result:The water extract and the 80% EtOH extract could lower the serum glucose levels 1 h and 2 h after glucose administration in normal or diabetic mice.And the water extract could lower the the serum glucose levels 2 h after given glucose in diabetic mice（P<0.05）;The blood glucose level was lower remarkably in the hyperglycemia mice that were administrated at high dose of the water extract of leaves of E.serratifolia（P<0.05）.Conclusion:The leaves of E.serratifolia could improve the glucose tolerance in normal and diabetic mice induced by STZ and also had an hypoglycemic effect on STZ induced diabetic mice.