Objective: To deal with the reactive essence between the Chinese materia medica（CMM） formula and human body: multiple genetic chromatodynamokinetics（pharmacodynamics with chromatographic fingerprint）

with‘Co-network compatibility and rainbow potential’according to properties and characteristics of disciplines.Method:The research characteristics of pharmacogenetics and pharmacy of CMM formula was analyzed

according to the effective mechanism of constitutes in CMM formula

combined with the requirements of modernization of CMM

to illuminate the modernization thoughts and methods of CMM.Result:The CMM formula

compared with west medicine

is an integer with multiple-constitutes carrying with original biologic genetic polymorphic information

synthesized out under primary and secondary metabolic enzymes

especially cytochrome P-450（CYP450） enzymes

imported into human body and metabolized by CYP450 enzymes

on metabolic actions with ‘co-network compatibility and rainbow potential’regularity

to show effects at end with receptors

similar to metabolic enzymes in primary channels of human being

with‘counter-treatment and complementation’reactions of multiple genetic chromatodynamokinetic by mass law.Conclusion:Conclusion:The pharmacodynamics essence between CMM formula and human body is multiple genetic chromatodynamokinetics among biology

abided by nature biology as common regularity

studied with biologic polymorphic methods.