Objective:To Compare the antiepileptic effect of vitamin plus Dingxian capsule with Dingxian capsule containing vitamin.Method:One hundred and twenty Kunming mice were randomly divided into 12 groups（PTZ group

sodium phenobarbital group

tested drugs Ⅰ group Ⅱ group;PTZ group

Valproate group

tested drugs Ⅲgroup

Ⅳgroup;pilocarpine group

sodium phenobarbital group

tested drugs Ⅴgroup Ⅵgroup）

n = 10 each respectively.With pentylenetetrazol and pilocarpine

epilepsy grand mal preparation

small seizures and psychomotor seizures model

were established.The seizure time within 30 minutes

frequency and time of death convulsions were observed and recorded.Result: Ⅰ and Ⅱ significantly prolonged the time of death（P<0.01）;Ⅱ couldsignificantly prolong epileptic seizures latency in mice（P<0.01）.Ⅲ and Ⅳ could significantly reduce seizure frequency（P<0.01）

prolong the time of death（P<0.01）

Ⅳ lowered seizures rate in mice（P<0.01）.Ⅴand Ⅵ Could extend significantly the time of death for psychomotor epilepsy（P<0.05）.Conclusion:Six tested drugs have significant effect for treatment of grand mal epilepsy

petit mal and psychomotor seizures induced by PTZ and pilocarpine.Dingxian capsule containing vitamin has a better role than vitamin plus Dingxian capsules for treament in seizures mice.