Objective:To investigate the hypoglycemic effect and its action mechanism of persimmon leaf polysaccharide in diabetic mice induced by streptozotocin（STZ）.Method:The diabetic mice were induced by STZ.Mice were randomly divided into 5 groups:control group

model group

glibenclamide group（25 mg·kg-1·d-1）

low and high dose groups of persimmon leaf polysaccharide（150 mg·kg-1·d-1

600 mg·kg-1·d-1）.The drugswere administrated to mice in every morning for 15 days.In the corresponding time

the contents of fasting blood glu-cose（FBG）

fasting insulin（FINS）

malondialdehyde（MDA）

superoide dismutase（SOD）activity

insulin sensi-tivity index（ISI）and oral glucose tolerance test（OGTT）were determined.Result:The persimmon leaf polysaccha-ride could markedly decrease blood glucose in STZ-induced diabetic mice.Meanwhile it could reduce the content ofMDA and increase the activity of SOD in liver

and increase insulin sensitivity index（ISI）and the amount of isletcells.Conclusion:The persimmon leaf polysaccharide decreases blood glucose

and it has a very potential value inthe treatment of diabetes.