Objective:To investigate the influence of Shenqi Feibao on rat model of chronic pulmonary dis-ease（COPD）and Qi Deficiency.Moethod:Wistar rat was employed in the study.COPD with Qi deficiency model was estbablished by smoke inhalation combined with papnin administration.Shenqi Feibao treatment was carried out meanwhile as the model was establishing.Two dose groups were designed as 12 and 6 g.kg-1 daily for 60 days.The general conditions

the changes in bronchial and lung and serum SOD

MDA of the rats were observed and deter-mined.Rsult:Shenqi Feibao could improve the systemic and respiratory conditions for the model rats

alleviate the injury in bronchina and lung tissues siginficantly

The high dose of the alleviate the injury in brochinal and lung tis-sues significantly.The high dose of the drug could significantly decrease MDA level compared with that of the model group（P < 0.05）.However

the level of SOD in the treatment groups did not change significantly compared with that of the model.Conclusion:Shenqi Feibao has the effect of protectiong airway mucosa

alleviatiing the injury in lung

and decreasing the serum level of MDA.So

to some degree

it may prevent the development of Qi deficiency.