Objective:To study the protection of anthraquinone of rhizoma polygoni cuspidati for the kid-neys of early diabetic nephropathy（DN） model rats.Method:DN rats were induced by streptozotocin（STZ）

which were randomized into high

middle and low dose of anthraquinone groups

control group with 15 in each

blank group with 10

model group with 16.The protection of anthraquinone of rhizoma polygoni cuspidati for the kidneys of early diabetic nephropathy model rats was synthetically evaluated by the changes concerning urine volume

mAlb and nephritic morphology before and after treatment.Result: Anthraxquinone of rhizoma polygoni cuspidati had no obvious effect on urine volume.High dosage and middle dosage of anthraquinone can lower mAlb level after 8 weeks of medication（P < 0.05）.High dosage and middle dosage of anthraquinone can lower serum glucose level

after 4 weeks of medication（P < 0.05）.Anthraxquinone of rhizoma polygoni cuspidati can effectively improve nephriticmorphology.Conclusion: Anthraquinone of rhizoma polygoni cuspidate owns protective effects on the kidneys of ear-ly diabetic nephropathy model rats.