Objective:To Compare the pharmacokinetics of ferulic acid after oral administration of the ex-tracts from Rhizoma Ligustici Chuanxiong and Tongmai formulations in rats.Method:The blood samples were col-lected at different time points after oral administration of the extracts from Rhizoma Ligustici Chuanxiong and Tong-mai formulations（equivalent to 9.0 mg.kg-1 ferulic acid） to wistar rats respectively.The plasma concentration of ferulic acid was measured by HPLC after extracted with ethyl acetate

and then pharmacokinetic parameters were cal-culated from the plasma concentration-time data with the 3P97 software.Result:The mean plasma concentration-time curves of ferulic acid after oral administration of the extracts from Rhizoma Ligustici Chuanxiong and Tongmai formu-lations were fitted to one compartment open model.The（Ke） s of the extracts from Rhizoma Ligustici Chuanxiong and Tongmai formulations were（0.015 ± 0.002）

（0.008 ± 0.001） min

t1/2（Ke） were（46.850 ± 5.414）

（87.033 ± 11.025）min respectively.Significant differences were found between the two groups（P < 0.01）.There existed significant differences（P < 0.05）in AUC and CL /F（s）between the extracts from Rhizoma Ligustici Chua-nxiong and Tongmai formulations.（AUC）s were（328.440 ± 115.461）

（625.718 ± 139.798）μg.min-1.mL-1

CL / F（s）were（0.032 ± 0.013）

（0.015 ± 0.004）L.kg-1.min-1 respectively.Conclusion:The work proved that the com-patibility of Radix Salviae Miltiorrhiza and Radix Puerahae with Rhizoma Ligustici Chuanxiong could reduce the elimi-nation rate

prolong the action time of ferulic acid in vivo and enhance the ferulic acid biological exploitability.