Objective:To investigate the pharmacokinetics of phillyrin and phillyrin-baicalin compound after intravenous injection（iv）in rabbits.Method: Ten rabbits were randomly divided into two groups.One group was administered with phillyrin（1 mg.kg-1） by iv

while the other were treated with phillyrin（1 mg.kg-1）-baicalin （90 mg.kg-1）compound by iv.The concentration of CA in plasma was determined by HPLC.The key parameters of pharmacokinetics were calculated and anylyzed by kinetic software.The calibration curve was linear（r = 0.997 3）in the range of 1.016-254 mg.L-1.Result: Concentration-time courses of phillyrin alone and phillyrin-baicalin compound were consistent with non-compartment model after iv.The key pharmacokinetic parameters of phillyrin alone were different with that of phillyrin-baicalin compound（P < 0.05）.Conclusion: Baicalin can affect the pharmacokinetics of constituent phillyrin in rabbits.