Objective:To introduce the research progress in chemical components

pharmacological actions and toxicity of Radix et Rhizoma Sophorae tonkinensis.Method: The relevant information and references were looked through

and further analyzed and reviewed.Result: Up to now

the chemical components isolated from S.tonkinensis include mainly flavonoids

alkaloids

polysaccharides

etc.Pharmacological references show that it has effects on antitumor

anti-inflammation

antimicrobial

hepatoprotection

immune stimulation

antiarrhythmia

anti-hypertension and so on.However

it may also induce toxicity such as hepatotoxicity

neurotoxicity

and gastrointes-tinal side effects.Conclusion: We should carry out further studies on mechanism-based antitumor activity and tox-icity for the radix et rhizoma S.tonkinensis

to determine the safe and effective therapeutic window

and even to ex-plore detoxification and enhancement actions by combing other medicines with it so to ensure its safe and effective-ness in clinic application.