Reported cases of adverse reaction of Chinese medicine injection has gradually increased.Safety issues for traditional Chinese medicine injection is questioned and unprecedented attention by the government

busi-ness

doctors

patients and rest of the society.It is imperative to establish an accurate

early

rapid detection meth-od for Chinese medicine allergic reaction.Screening allergenic substances in traditional Chinese medicine injection by in vivo and in vitro method is reviewed in this paper.These methods can provides a useful reference in exploring the allergen

selecting efficient sensitive detection of allergens

increasing the accuracy to resolve adverse effects of Chinese medicine injections and ensuring the clinical safety of drugs.