Objective:To observe the synergism of Shanzhayin gastric gavage and Yuyang Shengxin formula clysis in the treatment of immunity ulcerative colitis（UC） mices’ model therapeutic action and the relation between the effects and the dose

provide experiment basis for clinical application.Method:Selected 100 Kunming male mice and divided randomLy into five groups:normal group;model group;the Shanzhayin gastric gavage combined Yuyang Shengxin formula clysis high dose group and the low dose group;the salicylazosulfapyridine group.Except group A

the rest groups were made models

then gave them medicine after making model two days later.The mice in Group the Shanzhayin gastric gavage combined Yuyang Shengxin formula clysis high dose filled in the stomach with Shanzhayin 0.01 g.g-1 body weight and used the enema of Yuyang Shengxin formula 0.008 g.g-1 once a day.the low dose group filled in the stomach with Shanzhayin 0.005 g.g-1 body weight and used the enema of Yuyang Shengxin formula 0.004 g.g-1 once a day.The mice of the salicylazosulfapyridine group

were given intragastric administration and enema of 1% salicylazosulfapyridine with 0.000 2 g.g-1 once a day.The mice of normal group and the model group.were given intragastric administration and enema of normal saline with 0.02 mL.g-1 once a day.After 21 days of treatment

observed the changes of disease activity index（DAI） and body weight of mice in each group.Then killed the mice and took the total colon

got the colon’s wet weight and measured the colon weight index.Surveryed the conditions of colon inflamation reaction and the change of colon histopathology.Result:The DAI of mice

the changes of weight

the length conditions of eace group

the colon conditions of inflammation and ulcer reaction of eace group:made marks according to the criterion of colon inflammation and ulcer marking

the conditions of group the Shanzhayin gastric gavage combined Yuyang Shengxin formula clysis high dose

the low dose group and the salicylazosulfapyridine group were all better than model group.The difference was found in group the Shanzhayin gastric gravage combined Yuyang Shengxin formula clysis high dose

the low group and the Salicylazosulfapyridine group（P < 0.05）.Conclusion:Shanzhayin gastric gavage combined Yuyang Shengxin formula clysis showed better effects on the treatment of mice immunity ulcerative colitis:decreasd the marks of DAI

ulcer and inflammation

reduced colon congestion

edema

thickening of the inflammatory response

etc

improved significantly in mice immunity ulcerative colitis colon shorten degree

promoted mice ulcer healing and improved inflammatory reaction.Its curative effect and the dosage were positively correlated.