ZHANG Ye1, XIE Ming2, LIU Yue2. Effect of Different Formulas Correlated Therapy to Cytokines on Rats Model of Type 2 Diabetes Insulin Resistance[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(5): 210-212.
ZHANG Ye1, XIE Ming2, LIU Yue2. Effect of Different Formulas Correlated Therapy to Cytokines on Rats Model of Type 2 Diabetes Insulin Resistance[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(5): 210-212. DOI: 10.13422/j.cnki.syfjx.2011.05.018.
Objective:To investigate the effects of different formulas correlated therapy to cytokines in insu-lin resistant rats with type 2 diabetes mellitus(T2DM).Method:The research set on the rats model by feeding with high glucose and fat diet together with peritoneal injection of STZ.Fasting plasma glucose
fasting insulin
level of se-rum leptin
tumor necrosis factor ɑ and interleukin-6 of rats were tested when the experiment finished.The degree of insulin resistance was measured by insulin sensitivity index(ISI).Result:Compared with the model group
the level of FPG
Fins of formula Ⅰ(Yiqi Yangyin Huatan Huoxue) group were decreased obviously
the ISI level was in-creased obviously.The level of leptin
TNF-α
IL-6 were decreased obviously.Conclusions:Formula Ⅰ(Yiqi Yan-gyin Huatan Huoxue) is the best among different formulas correlated therapy.Formula Ⅰ(Yiqi Yangyin Huatan Huoxue)and Formula II(Yiqi Yangyin Huatan Jiangzhuo)have improvement effect on glucolipid metabolism to rats with type 2 diabetes mellitus