Objective:To observe anti-alcoholism effect of Yangyuan Decoction on drunken mice and rats.Method:The drunken model of mouse and rat was established through a single ig wine drink.Effects of Yangyuan Decoction（ig）were tested for prevention and treatment.The influence of Yangyuan Decoction on the disappearance of righting reflex and recovery time for drunken mice was observed.We employed gas chromatography to detect alco-hol concentration in rat serum.Result:The dose of 0.7

1.4 g.kg-1group of Yangyuan Decoction could significantly reduce the ethanol-induced sleep time in mice;the 0.35

0.7 g.kg-1dose group of Yangyuan Decoction could signif-icantly reduce alcohol concentration in rat serum.The effect was better than Neptune Jinzun.Conclusion:Anti-alco-holism effect of Yangyuan Decoction is likely achieved through mitigating gastrointestinal damage and speeding up alcohol metabolism in vivo.