LIU Xiu-feng, LIANG Mao-xin, ZHANG Hong. Effect of Buqi Xiaopi Decoction on Experimental Chronic Fatigue Syndrome[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(5): 219-222.
LIU Xiu-feng, LIANG Mao-xin, ZHANG Hong. Effect of Buqi Xiaopi Decoction on Experimental Chronic Fatigue Syndrome[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(5): 219-222. DOI: 10.13422/j.cnki.syfjx.2011.05.020.
补气消疲饮对实验性慢性疲劳综合征的影响
摘要
目的:观察补气消疲饮对实验性慢性疲劳综合征的影响。方法:实验分3组进行:第1组选用18~22 g ICR小鼠70只
SPF级
雌雄各半
每组10只
按体重随机分为7组
即空白对照组
模型对照组
补气消疲饮低、中、高(按生药量计6.5
13
26 g.kg-1.d-1)剂量组。生力胶囊(0.546 g.kg-1.d-1)组
复方氨基酸胶囊(0.273 g.kg-1.d-1)组
每天ig给药1次
连续7 d
测量并记录小鼠负重游泳时间、出离水迷宫时间以及脾脏质量;第2
3组实验动物、用药剂量、给药途径以及给药天数同第1组
复方氨基酸胶囊组改为醋酸地塞米松片(0.39 mg.kg-1.d-1)组
测定小鼠迟发超敏反应和血清溶血素含量的变化。结果:模型组
补气消疲饮低、中、高剂量组小鼠游泳时间分别为(1045±155)s
(1561±242)
(1958±605)
(2394±414)s
与模型组比较明显延长(P<0.01);出离水迷宫时间分别为(57±12)
(46±12)
(42±13)
(33±7)s
同模型组比较明显缩短(P<0.01);脾脏质量差异不显著;耳片质量之差分别为(1.85±0.55)
(1.54±0.57)
(1.29±0.71)
(0.84±0.46)g
A分别为0.593±0.315
0.701±0.360
0.829±0.166
0.929±0.290
同模型组比较耳片质量之差减小(P<0.01)
A值增大(P<0.01)。结论:补气消疲饮能够延长小鼠负重游泳时间、减少出离水迷宫时间
抑制2
4-二硝基氯苯所致迟发超敏反应、促进血清溶血素生成
具有抗疲劳、增强学习记忆能力和提高机体免疫力的作用。
Abstract
Objective:To observe the effect of Buqi Xiaopi decoction on experimental chronic fatigue syn-drome(CFS).Method:weight loading swimming time
passing morris water maze time
weight of spleen
delayed hypersensitive reaction(DHR)and serum hemolysin contents were selected to observe the effect of Buqi Xiaopi de-coction in mouse.Result:Buqi Xiaopi decoction could prolong the weight loading swimming time
reduce the passing morris water maze time
increase the weight of spleen
inhibit the DHR due to 2
4-dinitrochlorobenzene
and prove the serum hemolysin contents.Conclusion:Buqi Xiaopi decoction has the effect of antifatigue
improving learning and remembrance ability
immunity
so that it can be an effective traditional Chinese medicine prescription for CFS.The study establishes the foundation for clinical application and further researches.