Objective:To compare the different extraction techniques for Coptis and Magnolia and the changes of the main components in extracting Coptis and Magnolia with different proportion.Method:Coptis and Magnolia were extracted together or alone by using two kinds of solvents including water and alcohol with different propor-tions as 3:1

2:1

1:1

1:2 and 1:3 to determine the content of berberine

magnolol and honokiol by HPLC.Result:The extraction rate of Coptis and Magnolia with alcohol was better than that with water.The content of berberine was decreased 40% as extracting together by water

but was decreased only 1% as extracting together by alcohol.The content of magnolol and honokiol was increased 2% as extracting together with alcohol or water.The extraction rate of berberine was high when the ratio was 1:1.The higher of the extraction rate

the lower of the content of magnolol and honokiol would be.Conclusion:Coptis and Magnolia should be extracted together by alcohol.In the extraction process

in order to take the appropriate solvent and extraction methods

the chemical constituents of traditional Chinese medicine should be considered in different physical and chemical properties.