Objective:To determine 5 active compounds in Geranium sibiricum

namely gallic acid

protocat-echuin acid

quercetin

kaempferol-7-O-rhamnoside and kaemferitrin.Method:The HPLC method was applied and the separation was performed on an Agilent TC-C18 analytical column（4.6 mm × 250 mm

5 μm）.The mobile phase was methanol（A）-water containing 0.4% H3PO4（B） with gradient elution mode at the flow rate of 0.9 mL·min-1.The detection was set at 270 nm（0-23 min）

370 nm（23-55 min）

and the column temperature was 30 ℃.Result:The liner ranges of gallic acid

protocatechuin acid

quercetin

kaempferol-7-O-rhamnoside and kaemferitrin were 0.192-1.732 g·L-1（r = 0.999 7）

0.016-0.256 g·L-1（r = 0.999 9）

0.004-0.039 g·L-1（r = 0.999 9）

0.004-0.041 g·L-1（r = 0.999 9）

0.200 4-1.603 2 g·L-1（r = 0.999 8）.The average recoveries（n = 3） were 99.93%（RSD 1.5%）

97.27%（RSD 1.7%）

100.07%（RSD 2.2%）

99.92%（RSD 1.8%）

99.63%（RSD 1.0%）.Conclusion:The methord is simple and accurate with a good reproducibility and can be used as a quality control methord for G.sibiricum of different sources.