Objective:To observe the protective effect of Zuogui Jiangtang Qingzhi Recipe（ZJQR） on the liver steatosis in type 2 diabetes MKR mice.Method:Thirty MKR mice were randomly divided into the control group（CG）

the model group（MG） and the ZJQR group（ZG）.Except for CG mice which were raised by standard animal feeds

the others were all raised by high fat feeds to make liver steatosis model and after 8 weeks ZG were adminis-tered by ZJQR for 4 week.Histopathological changes were observed in the liver

including fasting blood-glucose（FBG）

insulin（INS） level

blood-lipid

liver quality

hepatosomatic index and liver function.Result:In the MG

the histopathological investigation showed increased fatty droplet within hepatocyte and fatty degeneration.As were liver quality

hepatosomatic index

the levels of FBG

INS

total cholesterol（TCHO）

high density lipoprotein cholesterol（HDL-C） and low-density lipoprotein cholesterol（LDL-C）（P < 0.05

P < 0.01）

but the level of triglycercide（TG） was reduced compared with CG（P < 0.01）.In the ZG

fatty degeneration within hepatocyte was improved·Liverquality

hepatosomatic index

the levels of FBG

INS

TCHO

LDL-C and TG were reduced（P < 0.05）

but HDL-C was enhanced compared with that in CG（P < 0.05

0.01）.Conclusion:ZGQR can significantly regulate glucose-lip-id metabolism

improve fatty degeneration and protect the liver.