Objective:To investigate the effects of Yiqi Buxue Recipe on peripheral blood cell counts of mice with myelosuppression induced by cyclophosphamide.Method:Kunming mice were used and randomly divided into 3 groups:normal control group

model group

Yiqi Buxue group（17.47 g.kg-1.d-1）.The marrow-depressed model were established by ip cyclophosphamide（CTX）100 mg.kg-1.d-1 to the mice for 3 d.The Yiqi Buxue group was given the recipe for 7days in advance before modeling until the end of the experiment.White blood cell（WBC）

red blood cell（RBC）and platelet（PLT）counts in peripheral blood of the mice were detected on 0

1

3

5

7

10 d days after model established.Result:After model was established

the WBC of the model group on 1

3 d were（1.19 ± 0.55） × 109 /L and（3.17 ± 1.20） × 109 /L

the Yiqi Buxue group were（2.05 ± 1.13） × 109 /L and（7.99 ± 5.70） × 109 /L（P < 0.01）.The PLT of the model group on 3

5 d were（406.60 ± 137.51）109 /L and（290.10 ± 104.58）109 /L

the Yiqi Buxue group were（644.20 ± 159.75）109 /L and（355.30 ± 72.06）109 /L（P < 0.05 or P < 0.01）

RBC had no change in the process.Conclusion:The Yiqi Buxue Recipe can ease the myelosup-pression induced by CTX and can accelerate the recovery of the WBC and PLT of mice.