Objective:To investigate influence of Dusuqing（DSQ）

a traditional Chinese medicine prescip-tion

on expression of inflammatory factor in lung tissue of rat models with bacterial pneumonia and phlegm-heat syn-drome and to reveal the mechanism of DSQ in treatment of the disease.Method:Wistar rats were randomized into five groups:normal

pneumonia

pneumonia with phlegm-heat syndrome

positive control and DSQ treated groups.Rat models with bacterial pneumonia accompanied by Phlegm-heat syndrome were made.The expressions of IL-1β

TNF-α

IL-6 and IL-10 proteins in lung tissue were analyzed by immunohistochemistry staining.The expression of IL-1βmRNA

IL-10mRNA was measured by RT-PCR.Result:The expressions of IL-1β

TNF-α

IL-6

IL-10

IL-1βmRNA and IL-10mRNA in pneumonia group and pneumonia with phlegm-heat syndrome group were markedly higher than those in normal control group（P < 0.01）.And in pneumonia with phlegm-heat syndrome group the ex-pressions of TNF-α

IL-6

IL-10 proteins and IL-10 mRNA were significantly higher than those in the pneumonia group（P < 0.01

P < 0.05）.Compared with pneumonia with phlegm-heat syndrome group

the expressions of IL-1β

TNF-α

IL-6 and IL-1β mRNA were markedly weakened in positive control group and DSQ treated group（P < 0.01） and the expressions in DSQ treated group were weaked significantly than those in positive control group（P < 0.05）.Compared with pneumonia with phlegm-heat syndrome group

the expressions of IL-10 protein and mRNA were en-hanced in DSQ treated group（P < 0.05）.Conclusion:The unbalance between proinflammatory and anti-inflammato-ry factor is involved in the pathological damage of lung tissues in pneumonia with phlegm-heat syndrome.The mecha-nism of DSQ in treating bacterial pneumonia with phlegm-heat syndrome may be related to its ability of inhibiting ex-cessive release of proinflammatory cytokine and promoting IL-10 secretion to regulate the balance between pro-and anti-inflammatory responses.