Objective:To investigate the anti-tumor effect of Rhaponticum uniflorum water extract（RUWE）in H22-bearing mice.Method:The H22 transplanted mouse models were established and randomly divided into 5 groups:model

high

medium and low dose RUWE

and 5-Fu group.Animals were treated with ig 400

200

100 mg.kg-1.d-1 RUWE once daily for 10 days

and with ip 5-Fu 25 mg.kg-1.d-1 every other day for 3 times

then the tumor growth in-hibition ratios

spleen and thymus indexes were caluclated.The serum tumor necrosis factor-α（TNF-α）and interlekin-2（IL-2）was determined with ELISA method

the total antioxidant capacity（T-AOC）and malondialdehyde（MDA）con-tent were detected by colorimetric method.Result:The administration with 400

200

100 mg.kg-1.d-1 RUWE inhibi-ted the growth of transplanted tumor with the inhibitory ratios of 38.05%

34.98%

26.95%

respectively.In addi-tion

RUWE treatment elevated the spleen index

reduced the serum TNF-α level

increased the serum T-AOC and de-creased serum MDA level of H22-bearing mice.Conclusion:RUWE could exhibit an inhibitory effect on the growth of transplanted H22 tumor

probably via the improved immune function and antioxdative capability.