Objective:The purpose of this study was to screen the effective herbal combination to resist ex-ercise-induced fatigue by decomposing Sijunzi decoction.Method:The total of 64 mice were randomly divided into four groups:Sijunzi decoction swimming group

Sijunzi decoction（no swimming）group

Dangshen group

and Baizhu-fuling group.There were 16 mice in each group.Animal model of exercise-induced fatigue was created by gradually increasing swimming time.Mice were killed four weeks later after exhausted swimming.Chang of indices including body weight of the mice

lactic acid（LD）

creatine kinase（CK）

liver glycogen（HG）

blood urea nitrogen（BUN）

lactate dehydrogenase（LDH） were tested.Result:There was no statistically significance of body weight

LD

HG

BUN and LDH between each group.CK level of Sijunzi decoction swimming group was significantly lower than other groups（P < 0.05）.BUN level of Dangshen decoction was significantly lower than other groups（P < 0.05）.Conclu-sion:Danshen resists exercise-induced fatigue by reducing BUN and Sijunzi decoction resists exercise-induced fa-tigue by reducing CK.