Objective:The present study aimed at comparing and analysing the effect of single chemothera-py and the chemotherapy combined with Cinobufagin in the medium and advanced esophageal patients

in order to the strength chemotherapy’s effects

improve the patients’ life qualities

and reduce the side effects.Method:Seventy cases of esophageal patients were randomLy divided into two groups

35 patients for each group.The control group were treated by the single ND chemotherapy

using NVB combined with DDP;while the treatment group were treated by 20 mL Cinobufagin injection and 500 mL 5% glucose infusion iv

once a day

at the same time with chemothera-py

the chemotherapy method was the same as the control group.We took 21 days as one period.After two weeks’ treatment

we analyzed the effect

the patients’ life qualities and the side effects of the two groups.Result:The effec-tive rate of treatment group and control group were 62.8%

48.5%

they have the statistic significance（P < 0.05）.The patients’ life qualities between the two groups have statistic significance（P < 0.05）.The treatment group’s side effects incidence rate was lower than the control group.Conclusion:The Cinobufagin injection combined with chem-otherapy had a better effect in the esophageal patients

reduced the side effects and improved the patients’ life quali-ties

deserved to be used in the clinical furtherly.