化学指标结合药效学指标优选紫金透骨喷雾剂提取工艺

郑林; 黄勇; 兰燕宇; 王永林; 迟明艳

doi:10.13422/j.cnki.syfjx.2011.13.026

您当前的位置：

首页 >

文章列表页 >

化学指标结合药效学指标优选紫金透骨喷雾剂提取工艺

工艺与制剂 | 更新时间：2024-09-23

- 化学指标结合药效学指标优选紫金透骨喷雾剂提取工艺
- Optimization of Extraction Technology of Zijintougu Sprays by Chemical Index with Pharmacodynamic Index
- 中国实验方剂学杂志 2011年17卷第13期页码：26-29
- 作者机构：
  
  贵阳医学院药学院
- 作者简介：
- 基金信息：
  
  贵州省中药现代化科技产业研究开发基金项目（黔科合社字[2008]5014号）;贵阳市科技计划项目（[2008]筑科农合同字第16号）
- DOI：10.13422/j.cnki.syfjx.2011.13.026
  中图分类号： R283.6
- 纸质出版日期：2011
- 稿件说明：
移动端阅览
[1]郑林,黄勇,兰燕宇,王永林,迟明艳.化学指标结合药效学指标优选紫金透骨喷雾剂提取工艺[J].中国实验方剂学杂志,2011,17(13):26-29.

ZHENG Lin, HUANG Yong, LAN Yan-yu, et al. Optimization of Extraction Technology of Zijintougu Sprays by Chemical Index with Pharmacodynamic Index[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(13): 26-29.
[1]郑林,黄勇,兰燕宇,王永林,迟明艳.化学指标结合药效学指标优选紫金透骨喷雾剂提取工艺[J].中国实验方剂学杂志,2011,17(13):26-29. DOI： 10.13422/j.cnki.syfjx.2011.13.026.

ZHENG Lin, HUANG Yong, LAN Yan-yu, et al. Optimization of Extraction Technology of Zijintougu Sprays by Chemical Index with Pharmacodynamic Index[J]. Chinese journal of experimental traditional medical formulae, 2011, 17(13): 26-29. DOI： 10.13422/j.cnki.syfjx.2011.13.026.

摘要

目的:用化学指标结合药效学指标评价紫金透骨喷雾剂不同提取工艺的科学性及合理性

优选紫金透骨喷雾剂的最佳提取工艺。方法:分别采用6种提取工艺制备紫金透骨喷雾剂样品

用HPLC测定白花丹醌、水杨酸甲酯和militarine含量

并观察6种工艺样品的抗急性软组织损伤作用和抗炎作用。结果:乙醇低温提取（渗漉、浸渍）样品的效果优于乙醇回流提取和水煎煮提取

且渗漉提取样品优于浸渍提取。结论:紫金透骨喷雾剂以乙醇渗漉提取工艺的综合指标优于其他工艺。

Abstract

Objective:To use chemical index and pharmacodynamics index to optimize the extraction technology of Zijintougu sprays.Method: six samples of Zijintougu sprays were prepared by different extraction technology.The content of plumbagin

methyl salicylate and militarine was determined in Zijintougu sprays by HPLC.The resistance to acute soft tissue injury and anti-inflammtory effect of 6 technological samples was observed.Result: Integrating the results of chemical index and pharmacodynamics index

the samples with ethanol low temperature extraction（percolation extraction

macerate extraction） were superior to the samples with ethanol refluxing extraction and water boiling extraction

and the sample with percolation extraction was superior to the sample with macerate extraction.Conclusion: The comprehensive indexes of Zijintougu sprays with ethanol percolation extraction were superior to that of other extraction technology.

关键词

Keywords

references

浏览量

126

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

工艺变更对祖师麻关节止痛膏体外释放及经皮渗透的影响

氮酮对跌打活络微乳喷雾剂体外透皮吸收影响的研究

高效液相色谱法测定紫金透骨喷雾剂中白花丹醌