Objective:To observe the effect of Dachengqi Decoction（DT）on inflammatory cytokines in rats suffered from the endotoxemia

and to discuss the mechanism of DT when curing the endotoxemia.Method: Fifty SD rats were divided into 5 groups randomly:sham operation group

model group

DT group

Rhei Radix et Rhizome group and Magnolia officinalis group.Two days before model establishment

rats were intervented by intragastric administration（1 g·kg-1）for the medication groups;and 1 hour after the last drug administration

model was established by CLP

then medication was continued for 3 days.The serum content of endotoxin

TNF-α

IL-1β and IL-10 was detected.Result: The content of plasma endotoxin

TNF-α

IL-1β and IL-10 was decreased evidently in curing group compared with those in the model group（P<0.01）.Concerning IL-1β/IL-10

model group（1.218 6±0.387 9）

DT group（0.389 1±0.223 9）

Radix Et Rhizome Rhea group（0.366 7±0.248 9）

M.officinalis group（0.372 5±0.185 8）

each treatment group compared with model group also had significant difference（P<0.01）.Conclusion: It shows that the mechanism of DT on endotoxemia is related with the antagonistic to the serum inflammatory cytokines TNF-α

IL-1β and the moderating effect to the ratio of IL-1β/IL-10.